Study links cognitive impairment, dementia to severe risk of Covid-19
Cognitive impairment, dementia are likely to be the risk factors for developing severe COVID-19, according to research from the University of Georgia. The results underscore the need for special care for populations with these pre-existing conditions during the pandemic.
The study was published online in the journal Brain, Behavior and Immunity.
In the study, researchers analyzed data from nearly 1,000 diseases and two specific genes to compare the health profiles of COVID-19 patients with those who test negative, looking for similarities in the patients. COVID-19.
The study drew on data from UK Biobank, a long-term study of over 500,000 participants studying the respective contributions of genetic predisposition and environmental exposure to disease development.
From March, UK Biobank began reporting the COVID-19 status of its participants. The team in the Department of Genetics at Franklin College of Arts and Sciences, led by Assistant Professor Kaixiong Ye and his postdoctoral fellow Jingqi Zhou, quickly connected COVID-19 status to electronic health data.
“We took a no-guesswork approach and the most statistically significant are cognitive impairment and type 2 diabetes,” said Ye, lead author of the study. “At the moment, we don’t know the mechanisms behind these associations, we only know that they are more common in COVID-19 patients.”
Analyzing the genetic factors that make some individuals more at risk for severe COVID-19, the team focused on two genes: ACE2 and TPMPRSS2, known to be essential for the virus to enter human cells. specific genetic variation is more common in the COVID-19 patient, ”he said. The research team also found that variations in genes linked to SARS-CoV-2 infection may be associated with severe COVID-19 that requires hospitalization.
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